Hydrochloric Acid → Methyl 6-(6-cyclopropyl-3,4'-bipyridine-2'-carboxamido)picolinate

HRID 92373Notes

Reaction equation

HRID 92373 reaction equation
[CH3:20][O:21][C:22]([c:23]1[n:24][c:25]([NH2:29])[cH:26][cH:27][cH:28]1)=[O:30].[CH3:55][N:56]1[CH2:57][CH2:58][O:59][CH2:60][CH2:61]1.[CH3:62][N:63]([CH3:64])[CH:65]=[O:66].[CH:2]1([c:5]2[cH:6][cH:7][c:8](-[c:11]3[cH:12][c:13]([C:17](=[O:18])[OH:19])[n:14][cH:15][cH:16]3)[cH:9][n:10]2)[CH2:3][CH2:4]1.[ClH:1].[F:31][P-:32]([F:33])([F:34])([F:35])([F:36])[F:37].[n:38]1([O:39][C:40]([N:41]([CH3:42])[CH3:43])=[N+:44]([CH3:45])[CH3:46])[c:47]2[n:48][cH:49][cH:50][cH:51][c:52]2[n:53][n:54]1>>[CH:2]1([c:5]2[cH:6][cH:7][c:8](-[c:11]3[cH:12][c:13]([C:17](=[O:19])[NH:29][c:25]4[n:24][c:23]([C:22]([O:21][CH3:20])=[O:30])[cH:28][cH:27][cH:26]4)[n:14][cH:15][cH:16]3)[cH:9][n:10]2)[CH2:3][CH2:4]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 13809143Methyl 6-aminopyridine-2-carboxylateHCID 58102927HCID 58102927, compound

Product 1

HCID 66848750Methyl 6-(6-cyclopropyl-3,4'-bipyridine-2'-carboxamido)picolinate

Sources & evidence

ORD record
ord-6fe70f8ff826438088b6bc12438cc3e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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