反应详情

To a solution of 1-cyclohexene-1,2-dicarboxylic anhydride (25.2 g) in tetrahydrofuran (125 mL) at 0° C. was added sodium borohydride (1.51 g). The mixture was warmed to ambient temperature for 30 minutes, heated at reflux for 5 hours, cooled, treated with 1N hydrochloric acid and concentrated. The concentrate was partitioned between ethyl acetate and brine, and the organic layer was washed with brine and water and concentrated. The concentrate was purified by flash chromatography with 50% ethyl acetate in hexane.

1. temperatureheated
2. temperatureat reflux for 5 hours
3. temperaturecooled
4. concentrationconcentrated
5. customThe concentrate was partitioned between ethyl acetate and brine
6. washthe organic layer was washed with brine and water
7. concentrationconcentrated
8. customThe concentrate was purified by flash chromatography with 50% ethyl acetate in hexane