Hydrochloric Acid → HCID 25122247, compound

HRID 925089Notes

Reaction equation

HRID 925089 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]2[C:14]3[NH:23][CH2:22][CH2:21][CH2:20][C:15]=3[C:16](=[O:19])[NH:17][N:18]=2)=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[Li+].[OH-].Cl>O1CCCC1.O>[F:1][C:2]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]2[C:14]3[NH:23][CH2:22][CH2:21][CH2:20][C:15]=3[C:16](=[O:19])[NH:17][N:18]=2)=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 25002582HCID 25002582, compound

Product 1

HCID 25122247HCID 25122247, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of EXAMPLE 506E (2.8 g, 8.8 mmol) in tetrahydrofuran (150 mL) was treated with LiOH (253 mg, 10.6 mmol) in water (20 mL) at 50° C. overnight. After cooling to room temperature, the mixture was acidified with dilute HCl to pH 4, and concentrated to about 10 mL. The solid material was collected by filtration, washed with water and dried to provide the title compound. MS (DCI/NH3) m/z 305 (M+H)+.

Workup

  1. concentrationconcentrated to about 10 mL
  2. filtrationThe solid material was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-3196e8c3669c499eb2a962203ce8e69c
Source dataset
uspto-grants-2016_03
Patent number
US09283222B2

Reaction notes

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