反应详情

A solution of compound 34e (293 mg, 1 eq.) and LiOH (49 mg, 4 eq) in H2O (5 mL) and THF (5 mL) was stirred at room temperature for 4 hrs. The reaction mixture was acidified with 1N HCl to pH 2 and then extracted with DCM. Organics were concentrated under reduced pressure and purified by chromatography on silica gel (DCM/MeOH) to yield compound 34f as beige solid in 80% yield. MS (ESI, EI+): m/z=601 (MH+).

1. extractionextracted with DCM
2. concentrationOrganics were concentrated under reduced pressure
3. custompurified by chromatography on silica gel (DCM/MeOH)