反应详情

温度

60 °C

To a mixture of 1.00 g of 2-(trimethylsilyl)ethyl 3-{[trans-4-(methoxycarbonyl)cyclohexyl]sulfamoyl}benzoate and 10 mL of DMF were added 0.63 g of 2-bromoethylmethyl ether and 0.94 g of potassium carbonate at room temperature, followed by stirring at 60° C. overnight. The reaction mixture was cooled to room temperature, and then water was added thereto, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine in this order, and dried over anhydrous sodium sulfate. The resultant was concentrated under reduced pressure, and to a mixture of the obtained residue and 10 mL of THF was added a solution of TBAF in THF (1.0 M, 4.0 mL), followed by stirring at room temperature for 3 hours. A solution of TBAF in THF (1.0 M, 2.0 mL) was further added thereto, followed by stirring at room temperature for 1.5 hours. The reaction mixture was diluted with ethyl acetate, and then washed with 0.2 M hydrochloric acid, water, and saturated brine in this order. The obtained organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure to obtain 915 mg of 3-{[trans-4-(methoxycarbonyl)cyclohexyl](2-methoxyethyl)sulfamoyl}benzoic acid as a colorless amorphous solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionfollowed by extraction with ethyl acetate
3. washThe organic layer was washed with water and saturated brine in this order
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationThe resultant was concentrated under reduced pressure
6. additionto a mixture of the obtained residue and 10 mL of THF
7. additionwas added a solution of TBAF in THF (1.0 M, 4.0 mL)
8. stirringby stirring at room temperature for 3 hours
9. additionA solution of TBAF in THF (1.0 M, 2.0 mL) was further added
10. stirringby stirring at room temperature for 1.5 hours
11. additionThe reaction mixture was diluted with ethyl acetate
12. washwashed with 0.2 M hydrochloric acid, water, and saturated brine in this order
13. dry with materialThe obtained organic layer was dried over anhydrous sodium sulfate
14. concentrationconcentrated under reduced pressure