Tetrahydrofuran → 2-(4-bromo-2-fluoroanilino)-N-[2-[tert-butyl(dimethyl)silyl]oxypropoxy]-1-methyl-6-oxopyridine-3-carboxamide
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:21])[c:5]([NH:8][c:9]2[n:10]([CH3:20])[c:11](=[O:19])[cH:12][cH:13][c:14]2[C:15]([O:17][CH3:16])=[O:18])[cH:6][cH:7]1.[C:22]([CH3:23])([CH3:24])([CH3:25])[Si:26]([O:27][CH:28]([CH2:29][O:30][NH2:31])[CH3:32])([CH3:33])[CH3:34].[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:35][Si:36]([N-:37][Si:38]([CH3:39])([CH3:40])[CH3:41])([CH3:42])[CH3:43].[Li+:44]>>[Br:1][c:2]1[cH:3][c:4]([F:21])[c:5]([NH:8][c:9]2[n:10]([CH3:20])[c:11](=[O:19])[cH:12][cH:13][c:14]2[C:15](=[O:17])[NH:31][O:30][CH2:29][CH:28]([O:27][Si:26]([C:22]([CH3:23])([CH3:24])[CH3:25])([CH3:33])[CH3:34])[CH3:32])[cH:6][cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-a9f32995f4cd44548136461dffdfcd81
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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