反应详情

温度

150 °C

DBU (4.50 equiv.) was added to a stirred, capped mixture of methyl 5-(2-benzyl-6-bromo-1-oxo-1,2-dihydroisoquinolin-3-yl)pentanoate (1 eq), Pd(OAc)2 (0.05 equiv.), molybdenum hexacarbonyl (1.0 equiv.) and (R)-1-(4-fluorophenyl)ethylamine (1.20 equiv.) in THF (0.2 M) and the mixture was stirred at 150° C. for 30 min. in a microwave. The mixture was purified by preparative TLC [1 mm] eluting with 50% EtOAc/hexanes to afford (R)-methyl 5-(2-benzyl-6-((1-(4-fluorophenyl)ethyl)carbamoyl)-1-oxo-1,2-dihydroisoquinolin-3-yl)pentanoate.

1. customcapped
2. customThe mixture was purified by preparative TLC [1 mm]
3. washeluting with 50% EtOAc/hexanes