tert-Butyl 3-(methylcarbamoyl)pentan-3-ylcarbamate → 2-Amino-2-ethyl-N-methyl-butyramide

HRID 927465Notes

Reaction equation

HRID 927465 reaction equation
[CH3:1][NH:2][C:3]([C:5]([NH:10]C(=O)OC(C)(C)C)([CH2:8][CH3:9])[CH2:6][CH3:7])=[O:4]>Cl.C(OCC)(=O)C>[NH2:10][C:5]([CH2:8][CH3:9])([CH2:6][CH3:7])[C:3]([NH:2][CH3:1])=[O:4]

Participants

4

Reactant 1

HCID 86674754tert-Butyl 3-(methylcarbamoyl)pentan-3-ylcarbamate

Product 1

HCID 798103702-Amino-2-ethyl-N-methyl-butyramideYield 75%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 3-(methylcarbamoyl)pentan-3-ylcarbamate (0.18 g, 0.74 mmol) in 10 ml saturated hydrochloride in ethyl acetate was stirred for 60 min at room temperature. Then the solution was evaporated to dryness to obtain the product (80 mg, 75%) as a light yellow solid; MS (LC/MS): 145.2 [M+H]+.

Workup

  1. customThen the solution was evaporated to dryness

Sources & evidence

ORD record
ord-573140ff27fb4a91acb1c9cefbce0f74
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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