Hydrochloric Acid → 2-(1,2,4-Oxadiazol-3-yl)propan-2-amine hydrochloride

HRID 927469Notes

Reaction equation

HRID 927469 reaction equation
[O:1]1[CH:5]=[N:4][C:3]([C:6]([NH:9]C(=O)OC(C)(C)C)([CH3:8])[CH3:7])=[N:2]1.[ClH:17]>C(OCC)(=O)C>[ClH:17].[CH3:7][C:6]([NH2:9])([C:3]1[N:4]=[CH:5][O:1][N:2]=1)[CH3:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73357654tert-butyl N-[2-(1,2,4-oxadiazol-3-yl)propan-2-yl]carbamate

Product 1

HCID 866747552-(1,2,4-Oxadiazol-3-yl)propan-2-amine hydrochlorideYield 94%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 2-(1,2,4-oxadiazol-3-yl)propan-2-ylcarbamate (0.668 g, 2.9 mmol) was dissolved in in ethyl acetate saturated with hydrochloride (10 mL) and stirred at room temperature for 0.5 h. Then it was concentrated to give product (0.45 g, 94%); MS (EI): m/e=128.2 [M+H]+.

Workup

  1. concentrationThen it was concentrated

Sources & evidence

ORD record
ord-58a50a08bd0b4c6ca898b831cb44e0af
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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