Diisobutylaluminum hydride → HCID 12306526, compound

HRID 929493Notes

Reaction equation

HRID 929493 reaction equation
[C:1]1([C:7]2[C:8](=[O:18])[O:9][CH2:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC(C[AlH]CC(C)C)C>C1COCC1>[C:1]1(/[C:7](=[C:11](\[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)/[CH2:10][OH:9])/[CH2:8][OH:18])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14487Diisobutylaluminum hydrideHCID 3440493,4-diphenyl-5H-furan-2-one

Product 1

HCID 12306526HCID 12306526, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

After dissolving compound 18 (1.00 g, 4.23 mmol) in THF (20 ml), the temperature was reduced to or and DIBAL-H (12.96 ml) was dropped. After the agitation for 3 hours was carried out, the reaction was terminated and the extraction was conducted with EA. The organic layer was washed five times with brine and the column chromatography was carried out to obtain compound 19.

Workup

  1. additionwas dropped
  2. customthe reaction was terminated
  3. extractionthe extraction
  4. washThe organic layer was washed five times with brine

Sources & evidence

ORD record
ord-173e62e61415495ea087ff4833a31c92
Source dataset
uspto-grants-2016_03
Patent number
US09296690B2

Reaction notes

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