Hydrochloric Acid → HCID 178479239, compound

HRID 929908Notes

Reaction equation

HRID 929908 reaction equation
C(OC([NH:8][CH2:9][C:10]([NH:12][C@@:13]1([C:28]([OH:30])=[O:29])[CH2:18][C@H:17]([S:19][C:20]2[NH:24][CH:23]=[N:22][N:21]=2)[C@@H:16]2[C@H:14]1[C@H:15]2[C:25]([OH:27])=[O:26])=[O:11])=O)(C)(C)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[NH2:8][CH2:9][C:10]([NH:12][C@@:13]1([C:28]([OH:30])=[O:29])[CH2:18][C@H:17]([S:19][C:20]2[NH:24][CH:23]=[N:22][N:21]=2)[C@@H:16]2[C@H:14]1[C@H:15]2[C:25]([OH:27])=[O:26])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453814HCID 178453814, compound

Product 1

HCID 178479239HCID 178479239, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Dissolve (1R,2S,4S,5R,6R)-2-[[-2-(tert-butoxycarbonylamino)acetyl]amino]-4-(4H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (220 mg, 0.49 mmol) in a saturated solution of hydrogen chloride gas in ethyl acetate (7 mL) and stir at room temperature for 2 hours. Remove the solvent to provide the title compound as a white solid (180 mg, 98%). MS (m/z): 342 (M+1).

Workup

  1. customRemove the solvent

Sources & evidence

ORD record
ord-9806be84dc2a4d57952a37e10f3779d5
Source dataset
uspto-grants-2016_03
Patent number
US09296710B2

Reaction notes

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