反应详情

To a solution of 2-bromo-4-fluorophenol (0.50 g, 2.6 mmol) in tetrahydrofuran (13 mL) were added cyclopropanemethanol (0.209 mL, 2.62 mmol), triphenylphosphine (0.687 g, 2.62 mmol), and DIAD (0.509 mL, 2.62 mmol). The reaction mixture was stirred for 16 hours at ambient temperature. The solvent was removed under reduced pressure. The residue was triturated with hexanes. The mixture was filtered, and the filtrate containing the product was concentrated by under reduced pressure. The residue was purified by flash chromatography (silica gel, hexanes) to provide the title compound (400 mg, 62% yield).

1. customThe solvent was removed under reduced pressure
2. customThe residue was triturated with hexanes
3. filtrationThe mixture was filtered
4. additionthe filtrate containing the product
5. concentrationwas concentrated by under reduced pressure
6. customThe residue was purified by flash chromatography (silica gel, hexanes)