Hydrochloric Acid → N-[2-Chloro-4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzyl]-butyramide

HRID 933554Notes

Reaction equation

HRID 933554 reaction equation
[C:1]([CH2:2][CH2:3][CH3:4])(=[O:5])[Cl:6].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:45][CH2:46][O:47][C:48]([CH3:49])=[O:50].[Cl:42][CH2:43][Cl:44].[ClH:7].[NH2:8][CH2:9][c:10]1[c:11]([Cl:34])[cH:12][c:13]([C:16](=[O:17])[N:18]2[c:19]3[c:20]([cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[NH:21][c:22]3[n:23]([CH3:28])[n:24][cH:25][c:26]3[CH2:27]2)[cH:14][cH:15]1>>[C:1]([CH2:2][CH2:3][CH3:4])(=[O:5])[NH:8][CH2:9][c:10]1[c:11]([Cl:34])[cH:12][c:13]([C:16](=[O:17])[N:18]2[c:19]3[c:20]([cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[NH:21][c:22]3[n:23]([CH3:28])[n:24][cH:25][c:26]3[CH2:27]2)[cH:14][cH:15]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 8471TriethylamineHCID 8855Butyryl chlorideHCID 8857Ethyl AcetateHCID 136128379[4-(Aminomethyl)-3-chlorophenyl]-(8-chloro-1-methyl-4,10-dihydropyrazolo[4,5-c][1,5]benzodiazepin-5-yl)methanone

Product 1

HCID 135736044N-[2-Chloro-4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzyl]-butyramide

Sources & evidence

ORD record
ord-73df46fbf2fd43ef9051521da76d7444
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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