Potassium Cation → Methyl 2-(5-bromopyridin-3-yloxy)-4-fluorobenzoate

HRID 933660Notes

Reaction equation

HRID 933660 reaction equation
[Br:1][c:2]1[cH:3][c:4]([OH:8])[cH:5][n:6][cH:7]1.[CH3:27][N:28]([CH3:29])[CH:30]=[O:31].[CH3:32][CH:33]1[CH2:34][CH2:35][CH2:36][O:37]1.[CH3:38][CH2:39][O:40][C:41](=[O:42])[CH3:43].[CH3:9][C:10]([CH3:11])([O-:12])[CH3:13].[F:15][c:16]1[c:17]([C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23][c:24]([F:26])[cH:25]1.[K+:14]>>[Br:1][c:2]1[cH:3][c:4]([O:8][c:16]2[c:17]([C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23][c:24]([F:26])[cH:25]2)[cH:5][n:6][cH:7]1

Participants

8

Reactant 7

HCID 813Potassium CationHCID 6228DimethylformamideHCID 73012-MethyltetrahydrofuranHCID 8857Ethyl AcetateHCID 5995293-Bromo-5-hydroxypyridineHCID 2782897Methyl 2,4-DifluorobenzoateHCID 45749132-Methylpropan-2-olate

Product 1

HCID 67227657Methyl 2-(5-bromopyridin-3-yloxy)-4-fluorobenzoate

Sources & evidence

ORD record
ord-78df82395b02423cabb929957e3c6f38
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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