Hydroxide → 2-(1-((((Tert-butoxy)carbonyl)amino)methyl)cyclohexyl)acetic acid

HRID 934891Notes

Reaction equation

HRID 934891 reaction equation
[Br:27][c:28]1[cH:29][cH:30][cH:31][c:32]([OH:34])[c:33]1[CH3:35].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]2([CH2:11][C:12]1=[O:13])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]2.[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[Li+:20].[OH-:19]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][C:10]1([CH2:11][C:12](=[O:13])[OH:34])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1

Participants

8

Reactant 7

HCID 961HydroxideHCID 8028TetrahydrofuranHCID 8058HexaneHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 111714303-Bromo-2-methylphenolHCID 685035643-Oxo-2-aza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

Product 1

HCID 27559412-(1-((((Tert-butoxy)carbonyl)amino)methyl)cyclohexyl)acetic acid

Sources & evidence

ORD record
ord-229af4ffd779441b89b93cb5a2b1a9e0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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