Hydrogen Bromide → 5-Bromo-1-chloroisoquinoline

HRID 935630Notes

Reaction equation

HRID 935630 reaction equation
[BrH:26].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]2[c:7]([NH2:12])[cH:8][cH:9][cH:10][c:11]12.[Cu:28].[NH2:18][C:19](=[O:20])[NH2:21].[Na+:13].[O-:14][N+:15](=[O:16])[O-:17].[O-:22][N+:23](=[O:24])[O-:25].[OH2:27]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]2[c:7]([Br:26])[cH:8][cH:9][cH:10][c:11]12

Participants

8

Reactant 7

HCID 260Hydrogen BromideHCID 923Sodium ionHCID 943Nitrate2×HCID 962WaterHCID 1176UreaHCID 23978CopperHCID 4597715-Amino-1-chloroisoquinoline

Product 1

HCID 211924975-Bromo-1-chloroisoquinoline

Sources & evidence

ORD record
ord-e5c41848fb2c4e5cabcded935a53b114
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…