Dimethylformamide → 3-Methyl-isoxazole-4-carboxylic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide

HRID 936527Notes

Reaction equation

HRID 936527 reaction equation
[CH3:1][c:2]1[n:3][o:4][cH:5][c:6]1[C:7](=[O:8])[OH:9].[CH3:20][CH2:21][N:22]=[C:23]=[N:24][CH2:25][CH2:26][CH2:27][N:28]([CH3:29])[CH3:30].[Cl:42][CH2:43][Cl:44].[NH2:31][CH:32]1[CH2:33][CH2:34][CH2:35][c:36]2[cH:37][cH:38][cH:39][cH:40][c:41]21.[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[OH:10][n:11]1[c:12]2[c:13]([cH:14][cH:15][cH:16][cH:17]2)[n:18][n:19]1>>[CH3:1][c:2]1[n:3][o:4][cH:5][c:6]1[C:7](=[O:9])[NH:31][CH:32]1[CH2:33][CH2:34][CH2:35][c:36]2[cH:37][cH:38][cH:39][cH:40][c:41]21

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 180661,2,3,4-Tetrahydro-1-naphthylamineHCID 757711-HydroxybenzotriazoleHCID 45896923-Methyl-1,2-oxazole-4-carboxylic acid

Product 1

HCID 111728863-Methyl-isoxazole-4-carboxylic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide

Sources & evidence

ORD record
ord-5c40b4553bab4c73b3b66aca0b4eb6a3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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