Hydrochloric Acid → 3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide
Reaction equation
[CH3:50][N:51]1[CH2:52][CH2:53][O:54][CH2:55][CH2:56]1.[Cl:62][CH:63]([Cl:64])[Cl:65].[ClH:16].[NH2:17][CH2:18][C:19]([C:20]([F:21])([F:22])[F:23])([OH:24])[CH3:25].[NH2:1][c:2]1[c:3]([C:13](=[O:14])[OH:15])[n:4][c:5]([Br:12])[c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[O:57]=[CH:58][N:59]([CH3:60])[CH3:61].[P-:26]([F:27])([F:28])([F:29])([F:30])([F:31])[F:32].[n:33]1([O:34][C:35]([N:36]([CH3:37])[CH3:38])=[N+:39]([CH3:40])[CH3:41])[c:42]2[n:43][cH:44][cH:45][cH:46][c:47]2[n:48][n:49]1>>[NH2:1][c:2]1[c:3]([C:13](=[O:15])[NH:17][CH2:18][C:19]([C:20]([F:21])([F:22])[F:23])([OH:24])[CH3:25])[n:4][c:5]([Br:12])[c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid
HCID 6212Chloroform
HCID 6228Dimethylformamide
HCID 79724-Methylmorpholine
HCID 9886Hexafluorophosphate
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 136207593-Amino-1,1,1-trifluoro-2-methylpropan-2-ol
HCID 584423503-Amino-6-bromo-5-(trifluoromethyl)picolinic acidProduct 1
Sources & evidence
- ORD record
- ord-1d06c6c04db54ffa900c76979ab91223
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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