1,2-Dichloroethane → 4-cyano-N-(4-propoxyphenylmethyl)piperidine

HRID 937026Notes

Reaction equation

HRID 937026 reaction equation
[Cl-:22].[Cl:29][CH2:30][CH2:31][Cl:32].[NH2:1][C:2](=[O:3])[CH:4]1[CH2:5][CH2:6][N:7]([CH2:10][c:11]2[cH:12][cH:13][c:14]([O:17][CH2:18][CH2:19][CH3:20])[cH:15][cH:16]2)[CH2:8][CH2:9]1.[Na+:21].[OH2:28].[P:23]([Cl:24])([Cl:25])([Cl:26])=[O:27]>>[N:1]#[C:2][CH:4]1[CH2:5][CH2:6][N:7]([CH2:10][c:11]2[cH:12][cH:13][c:14]([O:17][CH2:18][CH2:19][CH3:20])[cH:15][cH:16]2)[CH2:8][CH2:9]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 312ChlorideHCID 923Sodium ionHCID 962WaterHCID 24813Phosphorus oxychlorideHCID 190409324-aminocarbonyl-N-(4-propoxyphenylmethyl)piperidine

Product 1

HCID 190409134-cyano-N-(4-propoxyphenylmethyl)piperidine

Sources & evidence

ORD record
ord-ab5f4f94f0e044cfaf9f46cc3ae0c43f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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