Hydrochloric Acid → 1-[2-Hydroxy-(2-methoxyphenyloxy)-propyl]-piperidin-4-one

HRID 937494Notes

Reaction equation

HRID 937494 reaction equation
[C:54](=[O:55])([O-:56])[O-:57].[CH3:41][O:42][c:43]1[cH:44][cH:45][cH:46][cH:47][c:48]1[O:49][CH2:50][CH:51]1[O:52][CH2:53]1.[CH:60]([OH:61])([CH3:62])[CH3:63].[ClH:1].[ClH:33].[K+:58].[K+:59].[NH:34]1[CH2:35][CH2:36][C:37](=[O:40])[CH2:38][CH2:39]1.[OH:2][CH:3]([CH2:4][N:5]1[CH2:6][CH2:7][CH:8]([N:11]2[CH2:12][CH2:13][N:14]([c:15]3[cH:16][cH:17][cH:18][cH:19][cH:20]3)[C:21]2=[O:22])[CH2:9][CH2:10]1)[CH2:23][O:24][c:25]1[c:26]([O:31][CH3:32])[cH:27][cH:28][cH:29][cH:30]1>>[OH:2][CH:3]([CH2:4][N:5]1[CH2:6][CH2:7][C:8](=[O:40])[CH2:9][CH2:10]1)[CH2:23][O:24][c:25]1[c:26]([O:31][CH3:32])[cH:27][cH:28][cH:29][cH:30]1

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 813Potassium Cation2×HCID 3776IsopropanolHCID 19660Carbonate IonHCID 337214-PiperidoneHCID 98357((o-Methoxyphenoxy)methyl)oxiraneHCID 213293711-[1-[2-Hydroxy-3-(2-methoxyphenoxy)propyl]piperidin-4-yl]-3-phenylimidazolidin-2-one

Product 1

HCID 233473441-[2-Hydroxy-(2-methoxyphenyloxy)-propyl]-piperidin-4-one

Sources & evidence

ORD record
ord-e8a7f7f657514a9c85c440eb65894517
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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