Hydrochloric Acid → Methyl 5-(4-(1,1-difluoroethyl)phenyl)nicotinate

HRID 938740Notes

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH3:9])([F:10])[F:11])[cH:6][cH:7]1.[C:26](=[O:27])([O-:28])[O-:29].[CH3:13][O:14][C:15](=[O:16])[c:17]1[cH:18][c:19]([B:23]([OH:24])[OH:25])[cH:20][n:21][cH:22]1.[CH3:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[CH3:41][CH2:42][OH:43].[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[ClH:12].[F-:32].[K+:30].[K+:31].[K+:33].[OH2:44].[cH:51]1[cH:52][cH:53][c:54]([P:55]([Pd:56]([P:57]([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)([P:76]([c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)([c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[c:89]2[cH:90][cH:91][cH:92][cH:93][cH:94]2)[P:95]([c:96]2[cH:97][cH:98][cH:99][cH:100][cH:101]2)([c:102]2[cH:103][cH:104][cH:105][cH:106][cH:107]2)[c:108]2[cH:109][cH:110][cH:111][cH:112][cH:113]2)([c:114]2[cH:115][cH:116][cH:117][cH:118][cH:119]2)[c:120]2[cH:121][cH:122][cH:123][cH:124][cH:125]2)[cH:126][cH:127]1>>[c:2]1(-[c:19]2[cH:18][c:17]([C:15]([O:14][CH3:13])=[O:16])[cH:22][n:21][cH:20]2)[cH:3][cH:4][c:5]([C:8]([CH3:9])([F:10])[F:11])[cH:6][cH:7]1