Methanol → 7-(hydroxymethyl)-4-methyl-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one

HRID 939489Notes

Reaction equation

HRID 939489 reaction equation
[Al+3:20].[CH3:1][N:2]1[c:3]2[c:4]([cH:9][c:10]([C:13](=[O:14])[O:15][CH3:16])[cH:11][n:12]2)[NH:5][C:6](=[O:8])[CH2:7]1.[CH3:25][OH:26].[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[H-:18].[H-:19].[H-:22].[H-:23].[H-:24].[Li+:21].[Na+:17].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1.[OH2:32]>>[CH3:1][N:2]1[c:3]2[c:4]([cH:9][c:10]([CH2:13][OH:14])[cH:11][n:12]2)[NH:5][C:6](=[O:8])[CH2:7]1

Participants

10

Reactant 9

HCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride5×HCID 58324455Methyl 4-methyl-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylate

Product 1

HCID 583244317-(hydroxymethyl)-4-methyl-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one

Sources & evidence

ORD record
ord-c9aadacafad54047abb5c47a22e6c63e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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