Potassium Cation → 3-cyclohexyloxy-1-(4-fluoro-phenyl)-1H-pyrazin-2-one

HRID 939539Notes

Reaction equation

HRID 939539 reaction equation
[Br:15][c:16]1[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]1.[CH2:42]1[O:43][CH2:44][CH2:45][O:46][CH2:47]1.[CH3:23][NH:24][CH2:25][CH2:26][NH:27][CH3:28].[CH:1]1([O:7][c:8]2[c:9](=[O:14])[nH:10][cH:11][cH:12][n:13]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[Cu:48][I:49].[K+:34].[K+:35].[K+:36].[O:37]=[CH:38][N:39]([CH3:40])[CH3:41].[P:29]([O-:30])([O-:31])([O-:32])=[O:33]>>[CH:1]1([O:7][c:8]2[c:9](=[O:14])[n:10](-[c:16]3[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]3)[cH:11][cH:12][n:13]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

9

Reactant 8

HCID 813Potassium Cation3×HCID 1061PhosphateHCID 6228DimethylformamideHCID 8070N,N'-DimethylethylenediamineHCID 99931-Bromo-4-fluorobenzeneHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 575410493-(cyclohexyloxy)-2(1H)-pyrazinone

Product 1

HCID 679759613-cyclohexyloxy-1-(4-fluoro-phenyl)-1H-pyrazin-2-one

Sources & evidence

ORD record
ord-30c52d65bbf24cc3b7d5f76e5f1e83a9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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