Chloride → Diethyl methyl-(4-amino)benzylmalonate

HRID 939970Notes

Reaction equation

HRID 939970 reaction equation
[CH2:36]([N:37]([CH2:38][CH3:39])[CH2:40][CH3:41])[CH3:42].[CH3:27][CH2:28][O:29][C:30](=[O:31])[CH3:32].[CH3:33][CH2:34][OH:35].[Cl-:3].[N+:4]([O-:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]([CH2:11][C:12]([C:13](=[O:14])[O:15][CH2:16][CH3:17])([C:18](=[O:19])[O:20][CH2:21][CH3:22])[CH3:23])[cH:24][cH:25]1.[OH2:1].[OH2:26].[OH2:2]>>[NH2:4][c:7]1[cH:8][cH:9][c:10]([CH2:11][C:12]([C:13](=[O:14])[O:15][CH2:16][CH3:17])([C:18](=[O:19])[O:20][CH2:21][CH3:22])[CH3:23])[cH:24][cH:25]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 702EthanolHCID 962Water3×HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 54496963Diethyl 2-(4-nitrobenzyl)-2-methylmalonate

Product 1

HCID 54055855Diethyl methyl-(4-amino)benzylmalonate

Sources & evidence

ORD record
ord-8ca14057cd054103ab42472e2fd1b5e3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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