Dimethylformamide → (RS)-1-[2-(4,5-Difluoro-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone
Reaction equation
[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:14](=[O:15])[OH:16])[n:10][c:11]([CH3:13])[s:12]2)[cH:6][cH:7]1.[F:50][c:51]1[c:52]([F:67])[cH:53][cH:54][c:55]2[nH:56][c:57]([CH2:60][CH:61]3[NH:62][CH2:63][CH2:64][CH2:65][CH2:66]3)[n:58][c:59]12.[O:68]=[CH:69][N:70]([CH3:71])[CH3:72].[P-:17]([F:18])([F:19])([F:20])([F:21])([F:22])[F:23].[n:24]1([O:25][C:26]([N:27]([CH3:28])[CH3:29])=[N+:30]([CH3:31])[CH3:32])[c:33]2[n:34][cH:35][cH:36][cH:37][c:38]2[n:39][n:40]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:14](=[O:16])[N:62]3[CH:61]([CH2:60][c:57]4[nH:56][c:55]5[cH:54][cH:53][c:52]([F:67])[c:51]([F:50])[c:59]5[n:58]4)[CH2:66][CH2:65][CH2:64][CH2:63]3)[n:10][c:11]([CH3:13])[s:12]2)[cH:6][cH:7]1Participants
7
Reactant 6
HCID 6228Dimethylformamide
HCID 9886Hexafluorophosphate
HCID 81531Diisopropylethylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 17973676(RS)-4,5-Difluoro-2-piperidin-2-ylmethyl-1H-benzoimidazole
HCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidProduct 1
Sources & evidence
- ORD record
- ord-3c1a77aa381f4866bbd0d1995b2c1ae7
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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