Triethylamine → 1-(trans-4-Pentylcyclohexyl)-2-(3-fluoro-4-cyano-phenyl)-acetylene

HRID 941165Notes

Reaction equation

HRID 941165 reaction equation
[CH2:11]([CH2:12][CH2:13][CH2:14][CH3:15])[CH:16]1[CH2:17][CH2:18][CH:19]([C:22]#[CH:23])[CH2:20][CH2:21]1.[CH3:75][CH2:76][N:77]([CH2:78][CH3:79])[CH2:80][CH3:81].[CH:24]1([CH:25]=[O:26])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1.[Cu:73][I:74].[F:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([Br:10])[cH:9]1.[Pd:32]([Cl:33])[Cl:34].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1.[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1>>[F:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([C:23]#[C:22][CH:19]2[CH2:18][CH2:17][CH:16]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH2:21][CH2:20]2)[cH:9]1

Participants

8

Reactant 7

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 16275CyclohexanecarboxaldehydeHCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 7360294-Bromo-2-fluorobenzonitrileHCID 143657611-Ethynyl-4-pentylcyclohexane

Product 1

HCID 143657621-(trans-4-Pentylcyclohexyl)-2-(3-fluoro-4-cyano-phenyl)-acetylene

Sources & evidence

ORD record
ord-9eafcd77dc7a4705b0ad58c21c977667
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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