Water → 2-Butyl-5-(4-phenylpyridin-3-yloxy)isoindolin-1-one

HRID 941308Notes

Reaction equation

HRID 941308 reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[C:29](=[O:30])([O-:31])[O-:32].[CH2:14]([CH2:15][CH2:16][CH3:17])[N:18]1[C:19](=[O:28])[c:20]2[cH:21][cH:22][c:23]([OH:27])[cH:24][c:25]2[CH2:26]1.[CH3:36][N:37]1[CH2:38][CH2:39][CH2:40][C:41]1=[O:42].[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[Cs+:33].[Cs+:34].[Cu:43][I:44].[OH2:35]>>[c:2]1([O:27][c:23]2[cH:22][cH:21][c:20]3[c:25]([cH:24]2)[CH2:26][N:18]([CH2:14][CH2:15][CH2:16][CH3:17])[C:19]3=[O:28])[cH:3][n:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1

Participants

9

Reactant 8

HCID 962WaterHCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 27629283-Bromo-4-phenylpyridineHCID 138973842-Butyl-5-hydroxyisoindolin-1-one

Product 1

HCID 534772442-Butyl-5-(4-phenylpyridin-3-yloxy)isoindolin-1-one

Sources & evidence

ORD record
ord-321a9703474b4d3290bf8e58b3a07e5f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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