Tetrahydrofuran → 5'-fluoro-1'-{[5-(trifluoromethyl)-2-furyl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 941313Notes

Reaction equation

HRID 941313 reaction equation
[CH2:34]([P:35]([CH2:36][CH2:37][CH2:38][CH3:39])[CH2:40][CH2:41][CH2:42][CH3:43])[CH2:44][CH2:45][CH3:46].[F:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([CH2:11][c:12]1[o:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]1)[C:6](=[O:21])[C:5]2([CH2:22][OH:23])[c:24]1[cH:25][c:26]2[c:27]([cH:31][c:32]1[OH:33])[O:28][CH2:29][O:30]2.[N:47]([C:48]([O:49][C:50]([CH3:51])([CH3:52])[CH3:53])=[O:54])=[N:55][C:56]([O:57][C:58]([CH3:59])([CH3:60])[CH3:61])=[O:62].[O:63]1[CH2:64][CH2:65][CH2:66][CH2:67]1>>[F:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([CH2:11][c:12]1[o:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]1)[C:6](=[O:21])[C:5]21[CH2:22][O:33][c:32]2[c:24]1[cH:25][c:26]1[c:27]([cH:31]2)[O:28][CH2:29][O:30]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 97268Di-tert-butyl azodicarboxylateHCID 588724935-fluoro-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-dihydro-2H-indol-2-one

Product 1

HCID 592634755'-fluoro-1'-{[5-(trifluoromethyl)-2-furyl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-f2ae259d966342b7a406e30f43d81bca
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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