Propargyl alcohol → 3-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-prop-2-yn-1-ol

HRID 941874Notes

Reaction equation

HRID 941874 reaction equation
[CH2:18]([C:19]#[CH:20])[OH:21].[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[Cl:1][c:2]1[n:3][c:4]([N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([I:11])[s:10]2.[Cu:29]([I:30])[I:31].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[Cl:1][c:2]1[n:3][c:4]([N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([C:20]#[C:19][CH2:18][OH:21])[s:10]2

Participants

6

Reactant 5

HCID 7859Propargyl alcoholHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 83717Copper iodideHCID 595930614-(2-Chloro-6-iodothieno[3,2-d]pyrimidin-4-yl)morpholine

Product 1

HCID 866183933-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-prop-2-yn-1-ol

Sources & evidence

ORD record
ord-f7756cf7d8d44eb68d66437e207e567f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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