Hydrochloric Acid → Hydrochloric Acid

HRID 942248Notes

Reaction equation

HRID 942248 reaction equation
[CH3:21][O:22][c:23]1[cH:24][cH:25][c:26]([B:29]([OH:30])[OH:31])[cH:27][cH:28]1.[CH3:38][N:39]([CH3:40])[CH:41]=[O:42].[ClH:1].[N:2]12[CH2:3][CH:4]([CH2:10][C:11](=[O:12])[NH:13][c:14]3[cH:15][cH:16][c:17]([Br:20])[cH:18][cH:19]3)[CH:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9]2.[Na+:32].[Na+:33].[O-:34][C:35](=[O:36])[O-:37]>>[ClH:1].[N:2]12[CH2:3][CH:4]([CH2:10][C:11](=[O:12])[NH:13][c:14]3[cH:15][cH:16][c:17](-[c:26]4[cH:25][cH:24][c:23]([O:22][CH3:21])[cH:28][cH:27]4)[cH:18][cH:19]3)[CH:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9]2

Participants

8

Reactant 6

HCID 313Hydrochloric AcidHCID 923Sodium ion2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 201262(4-Methoxyphenyl)boronic acidHCID 218834492-(1-azabicyclo[2.2.2]octan-3-yl)-N-(4-bromophenyl)acetamide

Product 2

HCID 313Hydrochloric AcidHCID 218834732-(1-azabicyclo[2.2.2]octan-3-yl)-N-[4-(4-methoxyphenyl)phenyl]acetamide

Sources & evidence

ORD record
ord-80f537f788c0468999eb617d173cda38
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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