Dimethylformamide → 4,5-Difluoro-2-methoxy-4'-(3-nitro-benzyloxy)-biphenyl

HRID 942647Notes

Reaction equation

HRID 942647 reaction equation
[Br:6][CH2:7][c:8]1[cH:9][c:10]([N+:14](=[O:15])[O-:16])[cH:11][cH:12][cH:13]1.[CH3:34][Si:35]([N-:36][Si:37]([CH3:38])([CH3:39])[CH3:40])([CH3:41])[CH3:42].[CH3:44][CH2:45][O:46][C:47](=[O:48])[CH3:49].[F:17][c:18]1[cH:19][c:20]([O:32][CH3:33])[c:21](-[c:25]2[cH:26][cH:27][c:28]([OH:31])[cH:29][cH:30]2)[cH:22][c:23]1[F:24].[Li+:43].[O:1]=[CH:2][N:3]([CH3:4])[CH3:5]>>[CH2:7]([c:8]1[cH:9][c:10]([N+:14](=[O:15])[O-:16])[cH:11][cH:12][cH:13]1)[O:31][c:28]1[cH:27][cH:26][c:25](-[c:21]2[c:20]([O:32][CH3:33])[cH:19][c:18]([F:17])[c:23]([F:24])[cH:22]2)[cH:30][cH:29]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 77568Benzene, 1-(bromomethyl)-3-nitro-HCID 3280088Npc316347HCID 582599934',5'-Difluoro-2'-methoxy-biphenyl-4-ol

Product 1

HCID 582877964,5-Difluoro-2-methoxy-4'-(3-nitro-benzyloxy)-biphenyl

Sources & evidence

ORD record
ord-3813ed95858e4cc98ebe2660c6c89a84
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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