Hydrochloric Acid → 4-[2-(5-Bromo-pyridin-2-yloxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester
Reaction equation
[Br:21][c:22]1[cH:23][cH:24][c:25]([O:28][CH2:29][C:30](=[O:31])[OH:32])[n:26][cH:27]1.[CH2:12]([N:13]([CH:14]([CH3:15])[CH3:16])[CH:17]([CH3:18])[CH3:19])[CH3:20].[CH3:57][N:58]([CH3:59])[CH:60]=[O:61].[ClH:1].[NH2:2][c:3]1[c:4]([C:8](=[O:9])[O:10][CH3:11])[cH:5][s:6][cH:7]1.[OH2:62].[P-:33]([F:34])([F:35])([F:36])([F:37])([F:38])[F:39].[n:40]1([O:41][C:42]([N:43]([CH3:44])[CH3:45])=[N+:46]([CH3:47])[CH3:48])[c:49]2[n:50][cH:51][cH:52][cH:53][c:54]2[n:55][n:56]1>>[NH:2]([c:3]1[c:4]([C:8](=[O:9])[O:10][CH3:11])[cH:5][s:6][cH:7]1)[C:30]([CH2:29][O:28][c:25]1[cH:24][cH:23][c:22]([Br:21])[cH:27][n:26]1)=[O:31]Participants
9
Reactant 8
HCID 313Hydrochloric Acid
HCID 962Water
HCID 6228Dimethylformamide
HCID 9886Hexafluorophosphate
HCID 81531Diisopropylethylamine
HCID 3029122-[(5-Bromopyridin-2-yl)oxy]acetic acid
HCID 2777610Methyl 4-aminothiophene-3-carboxylate
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumProduct 1
Sources & evidence
- ORD record
- ord-9f20347f1e5248b78a83c62fafdea4e9
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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