Dimethylformamide → N'-({2-[5-(4-fluorobenzyl)-3-pyridin-4-yl-1H-pyrazol-1-yl]acetyl}oxy)pyrimidine-2-carboximidamide

HRID 943676Notes

Reaction equation

HRID 943676 reaction equation
[C:24]([n:25]1[cH:26][cH:27][n:28][cH:29]1)([n:30]1[cH:31][cH:32][n:33][cH:34]1)=[O:35].[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][c:7]2[cH:8][c:9](-[c:16]3[cH:17][cH:18][n:19][cH:20][cH:21]3)[n:10][n:11]2[CH2:12][C:13](=[O:14])[OH:15])[cH:22][cH:23]1.[O:51]=[CH:52][N:53]([CH3:54])[CH3:55].[OH:36][N:37]=[C:38]([NH2:39])[c:40]1[n:41][cH:42][cH:43][cH:44][n:45]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][c:7]2[cH:8][c:9](-[c:16]3[cH:17][cH:18][n:19][cH:20][cH:21]3)[n:10][n:11]2[CH2:12][C:13](=[O:14])[O:15][N:37]=[C:38]([NH2:39])[c:40]2[n:41][cH:42][cH:43][cH:44][n:45]2)[cH:22][cH:23]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 670925255-[(4-fluorophenyl)methyl]-3-(4-pyridinyl)-1H-Pyrazole-1-acetic acidHCID 136195713N'-hydroxypyrimidine-2-carboximidamide

Product 1

HCID 86617958N'-({2-[5-(4-fluorobenzyl)-3-pyridin-4-yl-1H-pyrazol-1-yl]acetyl}oxy)pyrimidine-2-carboximidamide

Sources & evidence

ORD record
ord-93e2716ea48a4f29b8e03fa2d71a56a9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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