Chloride → 4-(2-Cyanovinyl)-4-cyclohexylpiperidine-1-carboxylic acid tert-butyl ester

HRID 943875Notes

Reaction equation

HRID 943875 reaction equation
[C:23]([CH3:24])([CH3:25])([CH3:26])[O:27][C:28](=[O:29])[N:30]1[CH2:31][CH2:32][C:33]([CH:36]=[O:37])([CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)[CH2:34][CH2:35]1.[CH2:12]1[CH2:13][CH2:14][C:15]2=[N:20][CH2:19][CH2:18][CH2:17][N:16]2[CH2:21][CH2:22]1.[CH3:1][C:2]([C:3]#[N:4])([CH3:5])[P:6]([OH:7])([OH:8])=[O:9].[CH3:44][C:45]#[N:46].[Cl-:10].[Li+:11]>>[CH:2]([C:3]#[N:4])=[CH:36][C:33]1([CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)[CH2:32][CH2:31][N:30]([C:28]([O:27][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:29])[CH2:35][CH2:34]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 6342AcetonitrileHCID 28486Lithium ionHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 20250566Dimethyl phosphono acetonitrileHCID 219368754-Cyclohexyl-4-formylpiperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 695970864-(2-Cyanovinyl)-4-cyclohexylpiperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-bdc0193c62e54cc58425f25095f3130d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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