Chloride → (Oxan-2-yl)(piperazin-1-yl)methanone

HRID 944006Notes

Reaction equation

HRID 944006 reaction equation
[CH2:27]([N:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1)[c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[CH2:40]([c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1)[N:47]1[CH2:48][CH2:49][N:50]([C:53](=[O:54])[CH:55]2[O:56][CH2:57][CH2:58][CH2:59][CH2:60]2)[CH2:51][CH2:52]1.[Cl-:20].[Cl:21][C:22]([C:23]([Cl:24])=[O:25])=[O:26].[Na:1].[O:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH:16]1[C:17]([OH:18])=[O:19].[O:2]1[CH:3]=[CH:4][CH2:5][CH2:6][CH:7]1[C:8]([OH:9])=[O:10]>>[NH:47]1[CH2:48][CH2:49][N:50]([C:53](=[O:54])[CH:55]2[O:56][CH2:57][CH2:58][CH2:59][CH2:60]2)[CH2:51][CH2:52]1

Participants

8

Reactant 7

HCID 312ChlorideHCID 65578Oxalyl chlorideHCID 759941-BenzylpiperazineHCID 1181403,4-dihydro-2H-pyran-2-carboxylic acidHCID 5360545SodiumHCID 10964532Oxane-2-carboxylic acidHCID 20310402N-benzyl-N'-(tetrahydropyran-2-carbonyl)piperazine

Product 1

HCID 20385082(Oxan-2-yl)(piperazin-1-yl)methanone

Sources & evidence

ORD record
ord-9fc6cfb0ac9a494ea66326c6308f4430
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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