Water → 4-[8-Chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-2-(1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 945481Notes

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:35](=[O:36])[OH:37])[CH2:10][CH:11]([O:13][c:14]2[cH:15][c:16](-[c:27]3[s:28][cH:29][c:30]([CH:32]([CH3:33])[CH3:34])[n:31]3)[n:17][c:18]3[c:19]([Cl:26])[c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1.[CH2:49]([CH3:50])[O:51][C:52](=[O:53])[C:54]1([NH2:59])[CH:55]([CH:57]=[CH2:58])[CH2:56]1.[CH:60]([N:61]([CH:62]([CH3:63])[CH3:64])[CH2:65][CH3:66])([CH3:67])[CH3:68].[O:93]=[CH:94][N:95]([CH3:96])[CH3:97].[OH2:98].[OH:38][S:39]([c:40]1[cH:41][cH:42][c:43]([CH3:44])[cH:45][cH:46]1)(=[O:47])=[O:48].[P-:69]([F:70])([F:71])([F:72])([F:73])([F:74])[F:75].[n:76]1([O:77][C:78]([N:79]([CH3:80])[CH3:81])=[N+:82]([CH3:83])[CH3:84])[c:85]2[n:86][cH:87][cH:88][cH:89][c:90]2[n:91][n:92]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:35](=[O:36])[NH:59][C:54]2([C:52]([O:51][CH2:49][CH3:50])=[O:53])[CH:55]([CH:57]=[CH2:58])[CH2:56]2)[CH2:10][CH:11]([O:13][c:14]2[cH:15][c:16](-[c:27]3[s:28][cH:29][c:30]([CH:32]([CH3:33])[CH3:34])[n:31]3)[n:17][c:18]3[c:19]([Cl:26])[c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1