Dichloromethane → 1-Tert-butyl 3-methyl 1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

HRID 946534Notes

Reaction equation

HRID 946534 reaction equation
[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[CH3:39][N:40]([CH3:41])[c:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1.[Cl:48][CH2:49][Cl:50].[F:26][C:27]([F:28])([F:29])[C:30]([O:31][C:32](=[O:33])[C:34]([F:35])([F:36])[F:37])=[O:38].[OH:1][CH:2]1[CH:3]([C:15](=[O:16])[O:17][CH3:18])[CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[CH:2]1=[C:3]([C:15](=[O:16])[O:17][CH3:18])[CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 142844-(Dimethylamino)pyridineHCID 185348061-Tert-butyl 3-methyl 4-hydroxypiperidine-1,3-dicarboxylate

Product 1

HCID 111284441-Tert-butyl 3-methyl 1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

Sources & evidence

ORD record
ord-e19caef43b40479bb7d51999041a4c73
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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