Acetate → t-Butyl [3-(2-chloro-6,7-dimethoxyquinazolin-4-yl)phenyl]carbamate
Reaction equation
[B:17]([O-:18])([O-:33])[O:34][c:19]1[cH:20][c:21]([NH:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[cH:22][cH:23][cH:24]1.[C:43]([O-:44])(=[O:45])[CH3:46].[C:48]([O-:49])(=[O:50])[CH3:51].[CH3:52][CH2:53][O:54][C:55](=[O:56])[CH3:57].[Cl-:42].[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([O:15][CH3:16])[c:7]([O:13][CH3:14])[cH:8][c:9]2[c:10]([Cl:12])[n:11]1.[Na+:35].[Na+:36].[Na+:41].[O-:37][C:38](=[O:39])[O-:40].[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1.[Pd+2:47]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([O:15][CH3:16])[c:7]([O:13][CH3:14])[cH:8][c:9]2[c:10](-[c:19]2[cH:20][c:21]([NH:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[cH:22][cH:23][cH:24]2)[n:11]1Participants
10
Reactant 9
HCID 175Acetate2×
HCID 312Chloride
HCID 923Sodium ion3×
HCID 8028Tetrahydrofuran
HCID 8857Ethyl Acetate
HCID 19660Carbonate Ion
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 5203272,4-Dichloro-6,7-dimethoxyquinazoline
HCID 866503163-(N-t-butoxycarbonylamino)phenyl borateProduct 1
Sources & evidence
- ORD record
- ord-a4d4817706eb499c854640615fa9fcff
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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