Dimethylformamide → [4-(4-Chlorophthalazin-1-yl)-3-methylpiperazin-1-yl]-(4,4-difluorocyclohexyl)methanone

HRID 948878Notes

Reaction equation

HRID 948878 reaction equation
[CH3:50][CH2:51][O:52][C:53](=[O:54])[CH3:55].[CH3:56][CH2:57][N:58]([CH2:59][CH3:60])[CH2:61][CH3:62].[Cl:32][c:33]1[n:34][n:35][c:36]([N:43]2[CH:44]([CH3:49])[CH2:45][NH:46][CH2:47][CH2:48]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]12.[F:1][C:2]1([F:11])[CH2:3][CH2:4][CH:5]([C:8](=[O:9])[OH:10])[CH2:6][CH2:7]1.[O:12]=[C:13]1[N:14]([P:15]([Cl:16])([N:17]2[CH2:18][CH2:19][O:20][C:21]2=[O:22])=[O:23])[CH2:24][CH2:25][O:26]1.[O:27]=[CH:28][N:29]([CH3:30])[CH3:31]>>[F:1][C:2]1([F:11])[CH2:3][CH2:4][CH:5]([C:8](=[O:10])[N:46]2[CH2:45][CH:44]([CH3:49])[N:43]([c:36]3[n:35][n:34][c:33]([Cl:32])[c:42]4[c:37]3[cH:38][cH:39][cH:40][cH:41]4)[CH2:48][CH2:47]2)[CH2:6][CH2:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 27791364,4-Difluorocyclohexanecarboxylic acidHCID 766106781-Chloro-4-(2-methylpiperazin-1-yl)phthalazine

Product 1

HCID 76610690[4-(4-Chlorophthalazin-1-yl)-3-methylpiperazin-1-yl]-(4,4-difluorocyclohexyl)methanone

Sources & evidence

ORD record
ord-8e06a7689cab408abbb5092abcf3d59b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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