Toluene → 4,6-Dichloro-2-methylquinazoline

HRID 950484Notes

Reaction equation

HRID 950484 reaction equation
[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[CH3:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([OH:13])[n:6][c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1.[P:14]([Cl:15])([Cl:16])([Cl:17])=[O:18]>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([Cl:16])[n:6][c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 24813Phosphorus oxychlorideHCID 178433409HCID 178433409, compound

Product 1

HCID 210882724,6-Dichloro-2-methylquinazoline

Sources & evidence

ORD record
ord-8f294f0b22f64be999c4e15ef2ed92ce
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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