Acetic Acid → 4-(3-bromo-2-fluorophenyl)tetrahydro-2H-pyran-4-carbonitrile
Reaction equation
[Br:1][c:2]1[c:3]([F:11])[c:4]([CH2:8][C:9]#[N:10])[cH:5][cH:6][cH:7]1.[CH3:12][S:13]([CH3:14])=[O:15].[CH3:25][CH2:26][O:27][C:28](=[O:29])[CH3:30].[CH3:31][C:32](=[O:33])[OH:34].[Cl:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][Cl:24].[H-:16].[Na+:17]>>[Br:1][c:2]1[c:3]([F:11])[c:4]([C:8]2([C:9]#[N:10])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[cH:5][cH:6][cH:7]1Participants
8
Sources & evidence
- ORD record
- ord-79cbf3d071704cc9a8f7c5b1ebb09d86
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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