1,2-Dichloroethane → 2-Methyl-5-(4-{[3-(1H-pyrazol-1-yl)phenyl]acetyl}-1-piperazinyl)quinoline

HRID 951699Notes

Reaction equation

HRID 951699 reaction equation
[CH2:1]([Cl:2])[CH2:3][Cl:4].[CH3:16][c:17]1[n:18][c:19]2[cH:20][cH:21][cH:22][c:23]([N:27]3[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]3)[c:24]2[cH:25][cH:26]1.[CH3:48][N:49]([CH3:50])[CH:51]=[O:52].[ClH:5].[OH:6][n:7]1[c:8]2[c:9]([cH:10][cH:11][cH:12][cH:13]2)[n:14][n:15]1.[n:33]1(-[c:38]2[cH:39][c:40]([CH2:44][C:45](=[O:46])[OH:47])[cH:41][cH:42][cH:43]2)[n:34][cH:35][cH:36][cH:37]1>>[CH3:16][c:17]1[n:18][c:19]2[cH:20][cH:21][cH:22][c:23]([N:27]3[CH2:28][CH2:29][N:30]([C:45]([CH2:44][c:40]4[cH:39][c:38](-[n:33]5[n:34][cH:35][cH:36][cH:37]5)[cH:43][cH:42][cH:41]4)=[O:46])[CH2:31][CH2:32]3)[c:24]2[cH:25][cH:26]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 21062671[3-(1H-Pyrazol-1-yl)phenyl]acetic acidHCID 498519012-Methyl-5-piperazin-1-yl-quinoline

Product 1

HCID 498512602-Methyl-5-(4-{[3-(1H-pyrazol-1-yl)phenyl]acetyl}-1-piperazinyl)quinoline

Sources & evidence

ORD record
ord-d6297c76ffc142efbdd63b173f4a4d49
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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