Chloride → 2-(2-Chloro-5-methoxy-phenyl)-1-(2-chloro-pyridin-4-yl)-propan-1-ol

HRID 952202Notes

Reaction equation

HRID 952202 reaction equation
[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH:12]([Mg+:13])([CH3:14])[CH3:15].[Cl-:11].[Cl-:9].[Cl:16][c:17]1[c:18]([CH:25]([CH:26]=[O:27])[CH3:28])[cH:19][c:20]([O:23][CH3:24])[cH:21][cH:22]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([I:8])[cH:7]1.[Li+:10].[OH2:29]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH:26]([CH:25]([c:18]2[c:17]([Cl:16])[cH:22][cH:21][c:20]([O:23][CH3:24])[cH:19]2)[CH3:28])[OH:27])[cH:7]1

Participants

8

Reactant 7

HCID 312Chloride2×HCID 962WaterHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 15165112-Chloro-4-iodopyridineHCID 574499712-(2-Chloro-5-methoxy-phenyl)-propionaldehydeHCID 178461726HCID 178461726, compound

Product 1

HCID 866291052-(2-Chloro-5-methoxy-phenyl)-1-(2-chloro-pyridin-4-yl)-propan-1-ol

Sources & evidence

ORD record
ord-784ee149d678492ab9761f6b5cec1720
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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