HRID952953

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID312

Chloride

Cl-

HCID813

Potassium cation

K+

2 次

HCID962

Water

H2O

HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

HCID15413

Methyl tert-butyl ether

C5H12O

HCID19660

Carbonate

CO3-2

HCID58054609

未命名化合物

HCID135530832

未命名化合物

PRODUCTS

产物

HCID9933475

Cediranib

C25H27FN4O3

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-fbddbe052c33465b865cce4d07ff5356
来源数据集: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D
来源说明: Validation data from https://doi.org/10.1039/C8SC04228D

反应SMILES

[C:42](=[O:43])([O-:44])[O-:45].[CH2:2]1[CH2:3][CH2:4][N+:5]12[CH2:6][CH2:7][CH2:8][CH2:9]2.[CH3:35][N:36]1[CH2:37][CH2:38][CH2:39][C:40]1=[O:41].[CH3:49][O:50][C:51]([CH3:52])([CH3:53])[CH3:54].[Cl-:1].[F:10][c:11]1[c:12]2[cH:13][c:14]([CH3:34])[nH:15][c:16]2[cH:17][cH:18][c:19]1[O:20][c:21]1[n:22][cH:23][n:24][c:25]2[cH:26][c:27]([OH:33])[c:28]([O:31][CH3:32])[cH:29][c:30]12.[K+:46].[K+:47].[OH2:48]>>[CH2:2]([CH2:3][CH2:4][O:33][c:27]1[cH:26][c:25]2[n:24][cH:23][n:22][c:21]([O:20][c:19]3[c:11]([F:10])[c:12]4[cH:13][c:14]([CH3:34])[nH:15][c:16]4[cH:17][cH:18]3)[c:30]2[cH:29][c:28]1[O:31][CH3:32])[N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1