Hydrochloric Acid → 2-[(Biphenyl-4-ylmethyl)-amino]-1-[4-(2-chloro-phenoxy)-piperidin-1-yl]-ethanone

HRID 952957Notes

Reaction equation

HRID 952957 reaction equation
[Br:1][CH2:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:7][cH:8]1.[ClH:15].[Li+:35].[NH2:16][CH2:17][C:18](=[O:19])[N:20]1[CH2:21][CH2:22][CH:23]([O:26][c:27]2[c:28]([Cl:33])[cH:29][cH:30][cH:31][cH:32]2)[CH2:24][CH2:25]1.[O:37]=[CH:38][N:39]([CH3:40])[CH3:41].[OH-:34].[OH2:36]>>[CH2:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:7][cH:8]1)[NH:16][CH2:17][C:18](=[O:19])[N:20]1[CH2:21][CH2:22][CH:23]([O:26][c:27]2[c:28]([Cl:33])[cH:29][cH:30][cH:31][cH:32]2)[CH2:24][CH2:25]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 961HydroxideHCID 962WaterHCID 6228DimethylformamideHCID 28486Lithium ionHCID 2577161,1'-Biphenyl, 4-(bromomethyl)-HCID 593762772-Amino-1-[4-(2-chlorophenoxy)piperidin-1-yl]ethanone

Product 1

HCID 578745102-[(Biphenyl-4-ylmethyl)-amino]-1-[4-(2-chloro-phenoxy)-piperidin-1-yl]-ethanone

Sources & evidence

ORD record
ord-b6830a758b524f75913503d15484bd5d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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