Tetrahydrofuran → 5-Chloro-3-hydroxy-3-(3,5-dimethoxyphenyl)-1,3-dihydro-2H-indol-2-one
Reaction equation
[Br:2][c:3]1[cH:4][c:5]([O:11][CH3:12])[cH:6][c:7]([O:9][CH3:10])[cH:8]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[Cl:13][c:14]1[cH:15][c:16]2[c:20]([cH:21][cH:22]1)[NH:19][C:18](=[O:23])[C:17]2=[O:24].[Mg:1]>>[c:3]1([C:17]2([OH:24])[c:16]3[cH:15][c:14]([Cl:13])[cH:22][cH:21][c:20]3[NH:19][C:18]2=[O:23])[cH:4][c:5]([O:11][CH3:12])[cH:6][c:7]([O:9][CH3:10])[cH:8]1Participants
5
Sources & evidence
- ORD record
- ord-18a3f66135834e1bb6452a5cafdf706b
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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