Ammonium → N-[2-(3-cyclopropyl-1-hydroxycyclobutyl)-phenyl]Formamide

HRID 954974Notes

Reaction equation

HRID 954974 reaction equation
[Br:1][c:2]1[c:3]([NH:8][CH:9]=[O:10])[cH:4][cH:5][cH:6][cH:7]1.[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH3:31][CH2:32][O:33][C:34](=[O:35])[CH3:36].[CH:16]1([CH:19]2[CH2:20][C:21](=[O:23])[CH2:22]2)[CH2:17][CH2:18]1.[Cl-:24].[NH4+:25].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1>>[c:2]1([C:21]2([OH:23])[CH2:20][CH:19]([CH:16]3[CH2:17][CH2:18]3)[CH2:22]2)[c:3]([NH:8][CH:9]=[O:10])[cH:4][cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 8179142-BromoformanilideHCID 128200383-Cyclopropylcyclobutan-1-oneHCID 178418339Butyllithium

Product 1

HCID 86761115N-[2-(3-cyclopropyl-1-hydroxycyclobutyl)-phenyl]Formamide

Sources & evidence

ORD record
ord-e46665f6c9e548149b3a7a9b4a2e427a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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