Water → 2-Chloro-6-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl)-propyl]-phenoxy}-nicotinic acid methyl ester

HRID 955791Notes

Reaction equation

HRID 955791 reaction equation
[CH3:28][O:29][C:30](=[O:31])[c:32]1[c:33]([Cl:39])[n:34][c:35]([Cl:38])[cH:36][cH:37]1.[CH3:40][CH2:41][N:42]([CH2:43][CH3:44])[CH2:45][CH3:46].[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][cH:18][c:19]3[c:20]([n:21]([CH3:25])[c:22](=[O:24])[o:23]3)[cH:26]2)[CH3:27])[cH:4][cH:5][c:6]([OH:8])[cH:7]1.[N:47]12[CH2:48][CH2:49][N:50]([CH2:51][CH2:52]1)[CH2:53][CH2:54]2.[O:55]=[CH:56][N:57]([CH3:58])[CH3:59].[OH2:60]>>[Cl:1][c:2]1[c:3]([CH:9]([C:10]([C:11]([F:12])([F:13])[F:14])([OH:15])[c:16]2[cH:17][cH:18][c:19]3[c:20]([n:21]([CH3:25])[c:22](=[O:24])[o:23]3)[cH:26]2)[CH3:27])[cH:4][cH:5][c:6]([O:8][c:35]2[n:34][c:33]([Cl:39])[c:32]([C:30]([O:29][CH3:28])=[O:31])[cH:37][cH:36]2)[cH:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 9237DabcoHCID 11106516Methyl 2,6-dichloropyridine-3-carboxylateHCID 666969865-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3-methyl-3H-benzooxazol-2-one

Product 1

HCID 723101372-Chloro-6-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(3-methyl-2-oxo-2,3-dihydro-benzooxazol-5-yl)-propyl]-phenoxy}-nicotinic acid methyl ester

Sources & evidence

ORD record
ord-50c8f4fd40234e309399b9eb07d87851
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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