Hydrochloric Acid → 1-Chloro-2-(difluoromethoxy)-3-fluorobenzene

HRID 955863Notes

Reaction equation

HRID 955863 reaction equation
[C:10](=[O:11])([O-:12])[O-:13].[CH3:24][N:25]([CH3:26])[CH:27]=[O:28].[CH3:31][CH2:32][O:33][CH2:34][CH3:35].[Cl:16][C:17]([C:18]([O-:19])=[O:20])([F:21])[F:22].[Cl:1][c:2]1[c:3]([OH:9])[c:4]([F:8])[cH:5][cH:6][cH:7]1.[ClH:30].[K+:14].[K+:15].[Na+:23].[OH2:29]>>[Cl:1][c:2]1[c:3]([O:9][CH:17]([F:21])[F:22])[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 923Sodium ionHCID 962WaterHCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 27737102-Chloro-6-fluorophenolHCID 37630462-Chloro-2,2-difluoroacetate

Product 1

HCID 594321301-Chloro-2-(difluoromethoxy)-3-fluorobenzene

Sources & evidence

ORD record
ord-fa5a27243b594e05b163ca5d498340f0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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