Hydrochloric Acid → 1-Trityl-1H-imidazole-4-carboxylic acid 4-[4-(3,3-dimethyl-butyryl)-3-hydroxy-2-trifluoromethyl-phenoxymethyl]-benzylamide
Reaction equation
[C:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[n:31]1[cH:32][n:33][c:34]([C:36](=[O:37])[OH:38])[cH:35]1.[CH3:40][N:41]([CH3:42])[CH2:43][CH2:44][CH2:45][N:46]=[C:47]=[N:48][CH2:49][CH3:50].[CH3:80][CH2:81][N:82]([CH2:83][CH3:84])[CH2:85][CH3:86].[CH3:87][C:88]#[N:89].[ClH:39].[ClH:51].[NH2:52][CH2:53][c:54]1[cH:55][cH:56][c:57]([CH2:58][O:59][c:60]2[c:61]([C:74]([F:75])([F:76])[F:77])[c:62]([OH:73])[c:63]([C:66]([CH2:67][C:68]([CH3:69])([CH3:70])[CH3:71])=[O:72])[cH:64][cH:65]2)[cH:78][cH:79]1.[OH2:1].[OH:2][n:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[n:10][n:11]1>>[C:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[n:31]1[cH:32][n:33][c:34]([C:36](=[O:38])[NH:52][CH2:53][c:54]2[cH:55][cH:56][c:57]([CH2:58][O:59][c:60]3[c:61]([C:74]([F:75])([F:76])[F:77])[c:62]([OH:73])[c:63]([C:66]([CH2:67][C:68]([CH3:69])([CH3:70])[CH3:71])=[O:72])[cH:64][cH:65]3)[cH:78][cH:79]2)[cH:35]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid2×
HCID 962Water
HCID 6342Acetonitrile
HCID 8471Triethylamine
HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide
HCID 757711-Hydroxybenzotriazole
HCID 105701171-Trityl-1H-imidazole-4-carboxylic acid
HCID 671763681-[4-[[4-(Aminomethyl)phenyl]methoxy]-2-hydroxy-3-(trifluoromethyl)phenyl]-3,3-dimethylbutan-1-oneProduct 1
Sources & evidence
- ORD record
- ord-7ce971e8c0c14219a965f9bbb052f723
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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